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Flow Cytometry Datasets Associated with Single-cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment research
- Authors
- Cornish, Andrew Erickson
- Description
The purpose of the dataset from the Flow Repository: "To determine the degree to which populations of intratumoral T cells, especially but not limited to T regs, initially found in single cell RNA sequencing data may be reproduced in mass cytometry data." From the description on Flow Repository: The data included for each of the 3 patients (BC12, BC13, and BC14, respectively) is presented in nine...
- Subject
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Breast NeoplasmsGene Expression ProfilingGene Expression Regulation, NeoplasticImmunotherapyLeukocytes, MononuclearLymphocytes, Tumor-InfiltratingTumor Microenvironment/immunology
- Timeframe
- 2018
- Access Rights
- Free to All
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scRNA]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
- Subject
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Anemia, SideroblasticGene Expression ProfilingGenomicsHeteroplasmy/geneticsLeukocytes, MononuclearMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scATAC]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
- Subject
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Anemia, SideroblasticBinding sitesGenomicsHeteroplasmy/geneticsLeukocytes, MononuclearMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All
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High throughput joint profiling of chromatin accessibility and protein levels in single cells [PBMCs]
- Authors
- Mimitou, Eleni P.Lareau, Caleb A.Chen, Kelvin Y.Ludwig, Leif S.1 more author(s)...
- Description
Summary from GEO: "Recent technological advances have enabled massively parallel single-cell Assay for Transposase Accessible Chromatin by sequencing (scATAC-seq) to simultaneously profile the epigenomic landscape in thousands of individual cells. scATAC-seq methods sample genomic DNA accessible to transposases, but have not previously been combined with measurement of protein levels. Here, we present...
- Subject
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Cell DifferentiationGene Expression ProfilingHematopoiesisLeukocytes, Mononuclear
- Access Rights
- Free to All
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High throughput joint profiling of chromatin accessibility and protein levels in single cells [PBMC_Stim_Multiome]
- Authors
- Mimitou, Eleni P.Lareau, Caleb A.Chen, Kelvin Y.Ludwig, Leif S.1 more author(s)...
- Description
Summary from GEO: "Recent technological advances have enabled massively parallel single-cell Assay for Transposase Accessible Chromatin by sequencing (scATAC-seq) to simultaneously profile the epigenomic landscape in thousands of individual cells. scATAC-seq methods sample genomic DNA accessible to transposases, but have not previously been combined with measurement of protein levels. Here, we present...
- Subject
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CD28 AntigensCD3 ComplexCell DifferentiationChromatin Immunoprecipitation SequencingHematopoiesisLeukocytes, Mononuclear
- Access Rights
- Free to All